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Issue 35, 2010
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Raman and SERS spectroscopy of cucurbit[n]urils

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Cucurbit[n]urils (CB[n]) are a family of supramolecular hosts which can provide highly selective recognition based on their size (n). In this work we study their Raman spectroscopic signatures both experimentally and by molecular simulation and find systematic trends providing evidence of ring strain effects with size. Furthermore, we present for the first time their surface-enhanced Raman scattering (SERS) spectra utilizing both nanostructured surface and nanoparticle based approaches. Using SERS we can detect CB[n] at the ppb level and are able to distinguish between them in mixtures. Our study paves the way for utilization of CB[n] in highly sensitive, multiplexed, real time and high throughput molecular recognition assays based on SERS.

Graphical abstract: Raman and SERS spectroscopy of cucurbit[n]urils

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The article was received on 30 Mar 2010, accepted on 03 Jun 2010 and first published on 25 Jun 2010

Article type: Paper
DOI: 10.1039/C0CP00071J
Citation: Phys. Chem. Chem. Phys., 2010,12, 10429-10433
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    Raman and SERS spectroscopy of cucurbit[n]urils

    S. Mahajan, T. Lee, F. Biedermann, J. T. Hugall, J. J. Baumberg and O. A. Scherman, Phys. Chem. Chem. Phys., 2010, 12, 10429
    DOI: 10.1039/C0CP00071J

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