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Issue 48, 2010
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Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

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Abstract

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

Graphical abstract: Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

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Publication details

The article was received on 30 Jul 2010, accepted on 06 Oct 2010 and first published on 29 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02917C
Citation: Chem. Commun., 2010,46, 9116-9118
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    Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

    C. M. Lombardo, I. S. Martínez, S. Haider, V. Gabelica, E. De Pauw, J. E. Moses and S. Neidle, Chem. Commun., 2010, 46, 9116
    DOI: 10.1039/C0CC02917C

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