Issue 40, 2010
From the journal:

Chemical Communications

α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes†

James L. Galman,a   David Steadman,a   Sarah Bacon,b   Phattaraporn Morris,c   Mark E. B. Smith,a   John M. Ward,b   Paul A. Dalbyc  and  Helen C. Hailes*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK
E-mail: h.c.hailes@ucl.ac.uk
Fax: +44 (0)20 7679 7463
Tel: +44 (0)20 7679 4654

b Research Department of Structural & Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK

c Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

Graphical abstract: α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

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Article information

DOI
https://doi.org/10.1039/C0CC02911D
Article type
Communication
Submitted
30 Jul 2010
Accepted
25 Aug 2010
First published
10 Sep 2010

Chem. Commun., 2010,46, 7608-7610

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α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

J. L. Galman, D. Steadman, S. Bacon, P. Morris, M. E. B. Smith, J. M. Ward, P. A. Dalby and H. C. Hailes, Chem. Commun., 2010, 46, 7608 DOI: 10.1039/C0CC02911D

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