Issue 48, 2010
From the journal:

Chemical Communications

Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers†

Jason Shearer,*a   Paige E. Callan,a   Thao Tranb  and  Veronika A. Szalai‡*b  

* Corresponding authors

a Department of Chemistry, University of Nevada, Reno, USA
E-mail: shearer@unr.edu

b Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, USA
E-mail: vszalai@umbc.edu

Abstract

The fatal neurological disorder Alzheimer's disease has been linked to soluble neurotoxic oligomers of amyloid-β (Aβ) peptides. Herein we demonstrate that Cu1+ ligated within Aβ(42) oligomers (Aβ sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA) possesses a highly dioxygen sensitive tetrahedral coordination geometry. The biological implications of these findings are discussed.

Graphical abstract: Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

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Article information

DOI
https://doi.org/10.1039/C0CC02446E
Article type
Communication
Submitted
08 Jul 2010
Accepted
14 Oct 2010
First published
08 Nov 2010

Chem. Commun., 2010,46, 9137-9139

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Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

J. Shearer, P. E. Callan, T. Tran and V. A. Szalai, Chem. Commun., 2010, 46, 9137 DOI: 10.1039/C0CC02446E

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