A divergent synthesis of modular dendrimersvia sequential C–C bond fragmentation thio-Michael addition

Abstract

The C–C bond fragmentation of carbocycles has been developed as a new method for the divergent synthesis of dendrimers. The scope of this reaction was examined with the preparation of six first generation dendrimers from structurally diverse and readily available fragmentation precursors. By pairing the fragmentation with a thio-Michael reaction, the preparation of a [G4]-ene₂₄ dendrimer has been achieved.