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Issue 30, 2010
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Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

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Abstract

The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-19F-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.

Graphical abstract: Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of d-glucose and d-altrose and assessment of their erythrocyte transmembrane transport

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Publication details

The article was received on 26 Apr 2010, accepted on 24 May 2010 and first published on 07 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC01128B
Citation: Chem. Commun., 2010,46, 5434-5436
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    Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

    S. Bresciani, T. Lebl, A. M. Z. Slawin and D. O'Hagan, Chem. Commun., 2010, 46, 5434
    DOI: 10.1039/C0CC01128B

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