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Issue 24, 2010
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Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

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Abstract

Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

Graphical abstract: Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

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Publication details

The article was received on 24 Feb 2010, accepted on 20 Apr 2010 and first published on 13 May 2010


Article type: Communication
DOI: 10.1039/C0CC00107D
Citation: Chem. Commun., 2010,46, 4399-4401
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    Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

    D. T. Schühle, P. van Rijn, S. Laurent, L. Vander Elst, R. N. Muller, M. C. A. Stuart, J. Schatz and J. A. Peters, Chem. Commun., 2010, 46, 4399
    DOI: 10.1039/C0CC00107D

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