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Issue 23, 2010
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Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

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Abstract

Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

Graphical abstract: Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

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Publication details

The article was received on 11 Jan 2010, accepted on 04 Mar 2010 and first published on 19 Apr 2010


Article type: Feature Article
DOI: 10.1039/C000603C
Citation: Chem. Commun., 2010,46, 4021-4042
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    Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

    K. J. Hale, S. Manaviazar and J. George, Chem. Commun., 2010, 46, 4021
    DOI: 10.1039/C000603C

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