Issue 1, 2010

Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

Abstract

Pd/PtBu3-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.

Graphical abstract: Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

Supplementary files

Article information

Article type
Communication
Submitted
02 Sep 2009
Accepted
07 Oct 2009
First published
03 Nov 2009

Chem. Commun., 2010,46, 130-132

Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

Y. Jia, D. Katayev and E. P. Kündig, Chem. Commun., 2010, 46, 130 DOI: 10.1039/B917958E

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