Issue 8, 2010
From the journal:

Nanoscale

Development of nanoparticleprobes for multiplex SERS imaging of cell surfaceproteins†

David C. Kennedy,a   Kelly A. Hoop,b   Li-Lin Tayc  and  John Paul Pezacki*ab  

* Corresponding authors

a Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Canada
E-mail: John.Pezacki@nrc-cnrc.gc.ca

b Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada

c Institute for Microstructural Sciences, National Research Council Canada, 1200 Montreal Road, M-50, Ottawa, Canada

Abstract

Multiplexed SERS imaging of receptor proteins on the surface of mammalian cells has been carried out using functionalized silver nanoparticles. Deconvolution of four differently functionalized nanoparticles is readily achieved, and using this approach, receptor co-localization can be probed and protein–protein interactions can be elucidated at the surface of cells.

Graphical abstract: Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins

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Article information

DOI
https://doi.org/10.1039/C0NR00122H
Article type
Communication
Submitted
15 Feb 2010
Accepted
19 Apr 2010
First published
18 May 2010

Nanoscale, 2010,2, 1413-1416

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Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins

D. C. Kennedy, K. A. Hoop, L. Tay and J. P. Pezacki, Nanoscale, 2010, 2, 1413 DOI: 10.1039/C0NR00122H

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