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Department of Chemical & Biomolecular Engineering, Tulane University, New Orleans, USA
E-mail: vj@tulane.edu
; Fax: +1 504 865 6744
; Tel: +1 504 865 5883
Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, USA
E-mail: lbraud@tulane.edu
; Fax: +1 504 988 5144
; Tel: +1 504 988 2171
d
Department of Chemistry, Tulane University, New Orleans, USA
E-mail: garym@tulane.edu
; Fax: +1 504 865 5596
; Tel: +1 504 862 3570
Soft Matter, 2009,5, 3006-3009
DOI:
10.1039/B908779F
Received
05 May 2009,
Accepted
30 Jun 2009
First published online
10 Jul 2009
A dual-lipid liposome system consisting of a phospholipid and a skin ceramide extruded though a 100 nm membrane yields novel tubular and helical liposomes. These liposomes were used as templates to generate highly aspherical silica nanocapsules with length to diameter aspect ratios exceeding 10. Many of these nanocapsules have the morphology of a bulbous end attached to a long tip, mimicking microneedles attached to a reservoir. The fidelity of helical liposomes is transcribed to the silicas and the long tips indicate helically entwined left-handed silica structures. The silica coating is expected to protect and stabilize the internal contents of the liposomes, as well as enable surface functionalization for applications in drug or targeted delivery.
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