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Issue 24, 2009
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Nanofiber-supported phospholipid bilayers

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Abstract

The natural cell cytoskeleton provides critical mechanical support for lipid bilayers using a network of actin fibers. As a step towards fabricating artificial cells, functional nanofiber networks were created to mimic the chemical and mechanical environment provided by the actin network. Lipid bilayers were formed on a random nanofiber mat made from ∼131 nm diameter polycaprolactam nanofibers modified to be highly hydrophilic by coating with 6.6 nm of silica (SiO2). The nanofiber-supported bilayers were characterized using fluorescence recovery after photobleaching (FRAP) and electrophysiological recordings and found to be comparable to bilayer recordings from natural membranes. The nanofiber-supported bilayers were also more stable than conventional, unsupported, black lipid bilayers.

Graphical abstract: Nanofiber-supported phospholipid bilayers

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Publication details

The article was received on 13 Feb 2009, accepted on 28 Aug 2009 and first published on 19 Oct 2009


Article type: Paper
DOI: 10.1039/B903048D
Citation: Soft Matter, 2009,5, 5037-5041
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    Nanofiber-supported phospholipid bilayers

    F. Yi, J. Xu, A. M. Smith, A. N. Parikh and D. A. LaVan, Soft Matter, 2009, 5, 5037
    DOI: 10.1039/B903048D

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