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Issue 21, 2009
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Synthesis and application of bulky phosphoramidites: highly effective monophosphorus ligands for asymmetric hydrosilylation of styrenes

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Abstract

A series of bulky monodentate phosphoramidite ligands were synthesized from chiral 3,3′-diaryl substituted BINOL derivatives and achiral or dendritic amines in good yields. Asymmetric hydrosilylation of styrenes with trichlorosilane in the presence of palladium complexes of these bulky ligands gave chiral silanes in high yields with excellent activity and productivity. Oxidation of these chiral silanes with hydrogen peroxide gave the corresponding chiral secondary alcohols in up to 96% ee.

Graphical abstract: Synthesis and application of bulky phosphoramidites: highly effective monophosphorus ligands for asymmetric hydrosilylation of styrenes

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Publication details

The article was received on 12 May 2009, accepted on 21 Jul 2009 and first published on 20 Aug 2009


Article type: Paper
DOI: 10.1039/B909334F
Citation: Org. Biomol. Chem., 2009,7, 4470-4474
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    Synthesis and application of bulky phosphoramidites: highly effective monophosphorus ligands for asymmetric hydrosilylation of styrenes

    F. Zhang and Q. Fan, Org. Biomol. Chem., 2009, 7, 4470
    DOI: 10.1039/B909334F

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