Issue 16, 2009

Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Abstract

Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-α. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.

Graphical abstract: Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Supplementary files

Article information

Article type
Paper
Submitted
05 Feb 2009
Accepted
13 May 2009
First published
17 Jun 2009

Org. Biomol. Chem., 2009,7, 3230-3235

Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

B. A. Shah, R. Chib, P. Gupta, V. K. Sethi, S. Koul, S. S. Andotra, A. Nargotra, S. Sharma, A. Pandey, S. Bani, B. Purnima and S. C. Taneja, Org. Biomol. Chem., 2009, 7, 3230 DOI: 10.1039/B902041A

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