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Issue 1, 2009
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Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

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Abstract

A modular replacement approach to the synthesis of sulfo-nucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.

Graphical abstract: Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

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Publication details

The article was received on 28 Oct 2008, accepted on 29 Oct 2008 and first published on 17 Nov 2008


Article type: Communication
DOI: 10.1039/B819155G
Citation: Org. Biomol. Chem., 2009,7, 27-29
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    Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors

    J. H. Wong, U. Sahni, Y. Li, X. Chen and J. Gervay-Hague, Org. Biomol. Chem., 2009, 7, 27
    DOI: 10.1039/B819155G

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