Issue 4, 2009
From the journal:

Organic & Biomolecular Chemistry

Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. colimethionine repressor, MetJ, for its operator DNA†

Catherine Joce,ab   Jamie Caryl,b   Peter G. Stockley,b   Stuart Warrinerab  and  Adam Nelson*ab  

* Corresponding authors

a School of Chemistry, University of Leeds, Leeds, UK, UK
E-mail: a.s.nelson@leeds.ac.uk
Tel: +44 (0)113 3436502

b Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK

Abstract

The efficient synthesis of a range of stable SAM mimetics, and their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA, is described.

Graphical abstract: Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA

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Article information

DOI
https://doi.org/10.1039/B816495A
Article type
Communication
Submitted
22 Sep 2008
Accepted
08 Dec 2008
First published
19 Dec 2008
This article is Open Access

Org. Biomol. Chem., 2009,7, 635-638

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Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA

C. Joce, J. Caryl, P. G. Stockley, S. Warriner and A. Nelson, Org. Biomol. Chem., 2009, 7, 635 DOI: 10.1039/B816495A

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