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Issue 12, 2009
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Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

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Abstract

Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblastgrowth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.

Graphical abstract: Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

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Publication details

The article was received on 31 Mar 2009, accepted on 03 Jul 2009 and first published on 06 Aug 2009


Article type: Review Article
DOI: 10.1039/B906402H
Citation: Mol. BioSyst., 2009,5, 1456-1472
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    Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

    S. Lee, A. Brown, W. R. Pitt, A. P. Higueruelo, S. Gong, G. R. Bickerton, A. Schreyer, D. Tanramluk, A. Baylay and T. L. Blundell, Mol. BioSyst., 2009, 5, 1456
    DOI: 10.1039/B906402H

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