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Issue 5, 2009
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Antigen detection using polymerization-based amplification

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The influenza virus has been subtyped from crude lysates using polymerization-based amplification. In this novel chemical approach to detection, signal amplification was achieved by coupling a polymerization reaction to a proteinprotein recognition event. This particular method shows promise due to its advantages over the techniques currently employed in commercial assays in terms of cost, robustness, and unambiguity of test results. Instrumentation is not required to see the crosslinked hydrogel “readout”, and no false positives or false negatives were observed above the limit of detection.

Graphical abstract: Antigen detection using polymerization-based amplification

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The article was received on 16 Sep 2008, accepted on 20 Nov 2008 and first published on 08 Dec 2008

Article type: Communication
DOI: 10.1039/B816198D
Citation: Lab Chip, 2009,9, 653-656
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    Antigen detection using polymerization-based amplification

    H. D. Sikes, R. Jenison and C. N. Bowman, Lab Chip, 2009, 9, 653
    DOI: 10.1039/B816198D

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