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Issue 44, 2009
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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

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Abstract

Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3′-exonucleases.

Graphical abstract: Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

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Publication details

The article was received on 21 Aug 2009, accepted on 17 Sep 2009 and first published on 12 Oct 2009


Article type: Communication
DOI: 10.1039/B917312A
Citation: Chem. Commun., 2009,0, 6756-6758
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    Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA

    S. P. Sau, P. Kumar, B. A. Anderson, M. E. Østergaard, L. Deobald, A. Paszczynski, P. K. Sharma and P. J. Hrdlicka, Chem. Commun., 2009, 0, 6756
    DOI: 10.1039/B917312A

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