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Issue 36, 2009
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Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

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Abstract

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

Graphical abstract: Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

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Publication details

The article was received on 01 Jun 2009, accepted on 20 Jul 2009 and first published on 17 Aug 2009


Article type: Communication
DOI: 10.1039/B910677D
Citation: Chem. Commun., 2009,0, 5377-5379
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    Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

    B. Vaz, S. Möcklinghoff, S. Folkertsma, S. Lusher, J. de Vlieg and L. Brunsveld, Chem. Commun., 2009, 0, 5377
    DOI: 10.1039/B910677D

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