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Issue 45, 2009
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Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

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Abstract

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

Graphical abstract: Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

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Publication details

The article was received on 15 May 2009, accepted on 21 Sep 2009 and first published on 13 Oct 2009


Article type: Communication
DOI: 10.1039/B909666C
Citation: Chem. Commun., 2009, 7033-7035
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    Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

    J. A. I. Smith, J. Wang, S. Nguyen-Mau, V. Lee and H. O. Sintim, Chem. Commun., 2009, 7033
    DOI: 10.1039/B909666C

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