Copper(I) scorpionate complexes and their application in palladium-mediated [11C]carbonylation reactions

Steven Kealey; Philip W. Miller; Nicholas J. Long; Christophe Plisson; Laurent Martarello; Antony D. Gee

doi:10.1039/B906166E

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Copper(i) scorpionate complexes and their application in palladium-mediated [¹¹C]carbonylation reactions

Steven Kealey,^a Philip W. Miller,^a Nicholas J. Long,*^a Christophe Plisson,^b Laurent Martarello^b and Antony D. Gee*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Imperial College, London, UK
E-mail: n.long@imperial.ac.uk

^b GlaxoSmithKline, Clinical Imaging Centre, Imperial College, Hammersmith Hospital, London, UK
E-mail: antony.d.gee@gsk.com

Abstract

Solutions of copper(I) tris(pyrazolyl)borate complexes have been used to greatly improve the solubility of [¹¹C]carbon monoxide, enabling it to be used in low-pressure, ‘one-pot’ palladium-mediated carbonylation reactions to form ¹¹C-radiolabelled amides and ureas for use in positron emission tomography.

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Article information

DOI: https://doi.org/10.1039/B906166E
Article type: Communication
Submitted: 30 Mar 2009
Accepted: 23 Apr 2009
First published: 07 May 2009

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Chem. Commun., 2009, 3696-3698

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Copper(I) scorpionate complexes and their application in palladium-mediated [¹¹C]carbonylation reactions

S. Kealey, P. W. Miller, N. J. Long, C. Plisson, L. Martarello and A. D. Gee, Chem. Commun., 2009, 3696 DOI: 10.1039/B906166E

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Chemical Communications