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Issue 26, 2009
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Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

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Abstract

An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.

Graphical abstract: Base and copper(i) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

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Publication details

The article was received on 20 Mar 2009, accepted on 11 May 2009 and first published on 01 Jun 2009


Article type: Communication
DOI: 10.1039/B905629G
Citation: Chem. Commun., 2009,0, 3916-3918
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    Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

    H. Wang, T. Yang, P. Xu and D. J. Dixon, Chem. Commun., 2009, 0, 3916
    DOI: 10.1039/B905629G

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