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Issue 12, 2009
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Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

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Abstract

The combination of IrCl(CO)(PPh3)2 with 1,1,3,3-tetramethyldisiloxane or poly(methylhydrosiloxane) (PMHS) is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides; in particular, facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS.

Graphical abstract: Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

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Publication details

The article was received on 27 Nov 2008, accepted on 08 Jan 2009 and first published on 02 Feb 2009


Article type: Communication
DOI: 10.1039/B821317H
Citation: Chem. Commun., 2009,0, 1574-1576
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    Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

    Y. Motoyama, M. Aoki, N. Takaoka, R. Aoto and H. Nagashima, Chem. Commun., 2009, 0, 1574
    DOI: 10.1039/B821317H

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