Issue 1, 2008

A microwave assisted intramolecular-furan-Diels–Alder approach to 4-substituted indoles

Abstract

The key steps of a versatile new protocol for the convergent synthesis of 3,4-disubstituted indoles are the addition of an α-lithiated alkylaminofuran to a carbonyl compound, a microwave-accelerated intramolecular Diels–Alder cycloaddition and an in situ double aromatization reaction.

Graphical abstract: A microwave assisted intramolecular-furan-Diels–Alder approach to 4-substituted indoles

Supplementary files

Article information

Article type
Communication
Submitted
29 Sep 2008
Accepted
30 Oct 2008
First published
11 Nov 2008

Chem. Commun., 2008

A microwave assisted intramolecular-furan-Diels–Alder approach to 4-substituted indoles

F. Petronijevic, C. Timmons, A. Cuzzupe and P. Wipf, Chem. Commun., 2008 DOI: 10.1039/B816989F

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