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Issue 28, 2009
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Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

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Abstract

A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral γ-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

Graphical abstract: Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

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Publication details

The article was received on 11 Mar 2009, accepted on 19 May 2009 and first published on 10 Jun 2009


Article type: Communication
DOI: 10.1039/B905033G
Citation: Chem. Commun., 2009, 4251-4253
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    Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates

    H. Lu, X. Wang, C. Yao, J. Zhang, H. Wu and W. Xiao, Chem. Commun., 2009, 4251
    DOI: 10.1039/B905033G

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