Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

Lili Cheng; Huiling Tan; Xiaoyu Wu; Ruijun Hu; Carlin Aw; Min Zhao; Han-Ming Shen; Yixin Lu

doi:10.1039/B813904K

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Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells†

Lili Cheng,^a Huiling Tan,^b Xiaoyu Wu,^a Ruijun Hu,^a Carlin Aw,^a Min Zhao,^b Han-Ming Shen*^b and Yixin Lu*^ac

Author affiliations

* Corresponding authors

^a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, Republic of Singapore
E-mail: chmlyx@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-1569

^b Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive, Singapore, Republic of Singapore
E-mail: cofshm@nus.edu.sg
Fax: (+65) 6779-1489

^c Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Republic of Singapore

Abstract

Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-α-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-α-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy.

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Supplementary files

Experimental procedures and characterization of the novelluteolin analogues; details of the cytotoxicity studies andsensitization experiments; ¹H NMR spectra of the products PDF (1019K)

Article information

DOI: https://doi.org/10.1039/B813904K
Article type: Communication
Submitted: 12 Aug 2008
Accepted: 24 Sep 2008
First published: 09 Oct 2008

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Org. Biomol. Chem., 2008,6, 4102-4104

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Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

L. Cheng, H. Tan, X. Wu, R. Hu, C. Aw, M. Zhao, H. Shen and Y. Lu, Org. Biomol. Chem., 2008, 6, 4102 DOI: 10.1039/B813904K

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Organic & Biomolecular Chemistry

Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells†

Abstract

Supplementary files

Article information

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Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

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