Issue 24, 2008

Fluorescent labeling of peptides on solid phase

Abstract

N α-Fmoc-Nε-[(7-methoxycoumarin-4-yl)acetyl]-L-lysine (Nα-Fmoc-L-Lys(Mca)-OH) 3 is conveniently prepared by benzotriazole methodology (52% over two steps). N-Acylbenzotriazoles Mca-Bt 2, Nα-Fmoc-L-Lys(Mca)-Bt 4, coumarin-3-ylcarbonyl (Cc)-Bt 5, Nα-Fmoc-L-Lys(Cc)-Bt 7 and Nα-(Cc)-L-Lys(Fmoc)-Bt 9 enable the efficient microwave enhanced solid-phase fluorescent labeling of peptides.

Graphical abstract: Fluorescent labeling of peptides on solid phase

Supplementary files

Article information

Article type
Paper
Submitted
09 Jul 2008
Accepted
16 Sep 2008
First published
30 Oct 2008

Org. Biomol. Chem., 2008,6, 4582-4586

Fluorescent labeling of peptides on solid phase

A. R. Katritzky, M. Yoshioka, T. Narindoshvili, A. Chung and J. V. Johnson, Org. Biomol. Chem., 2008, 6, 4582 DOI: 10.1039/B811693H

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