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Issue 12, 2008
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Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

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Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Graphical abstract: Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

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Publication details

The article was received on 22 Feb 2008, accepted on 15 Apr 2008 and first published on 24 Apr 2008


Article type: Communication
DOI: 10.1039/B803107J
Citation: Org. Biomol. Chem., 2008,6, 2058-2060
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    Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

    K. Nakamura, Y. Tachikawa, M. Kitamura, O. Ohno, M. Suganuma and D. Uemura, Org. Biomol. Chem., 2008, 6, 2058
    DOI: 10.1039/B803107J

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