Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based system that permits conditional transgene expression. Such methodologies promise to enable new zebrafish models for interrogating human physiology and disease.
H. Esengil and J. K. Chen, Mol. BioSyst., 2008, 4, 300 DOI: 10.1039/B718447F
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