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Issue 43, 2008
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First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells

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Abstract

A diazole is N-substituted with 1-trityl-2-methylaziridine and demethylated and oxidised with NBS under acidic conditions to give a benzimidazolequinone; this novel anti-tumour agent is marginally more cytotoxic than mitomycin C (MMC) towards the normal human fibroblast cell line GM00637, while the MMC-hypersensitive human Fanconi anaemia (FA) cell line, PD20i, lacking the FANCD2 protein, is also hypersensitive to the benzimidazolequinone, with expression of FANCD2 protein decreasing sensitivity to both MMC and the benzimidazolequinone.

Graphical abstract: First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells

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Publication details

The article was received on 22 Aug 2008, accepted on 03 Sep 2008 and first published on 29 Sep 2008


Article type: Communication
DOI: 10.1039/B814706J
Citation: Chem. Commun., 2008, 5592-5594
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    First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells

    L. O’Donovan, M. P. Carty and F. Aldabbagh, Chem. Commun., 2008, 5592
    DOI: 10.1039/B814706J

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