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Issue 31, 2008
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Phosphate esters as “tunable” reagents in organic synthesis

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The essential role phosphates have in biochemistry has no parallel in man-made chemistry, where the poor reactivity of these esters towards nucleophilic substitution makes more reactive substrates such as halides and sulfonates preferred. Nevertheless, phosphates are acquiring an increasing role in organic synthesis as long as new activation modes become available. These include metal catalysis and photochemistry (the latter effective with benzyl and aryl derivatives) that may turn the present limitation into a promising opportunity by devising convenient tunable reactions.

Graphical abstract: Phosphate esters as “tunable” reagents in organic synthesis

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The article was received on 01 Feb 2008, accepted on 22 May 2008 and first published on 27 Jun 2008

Article type: Feature Article
DOI: 10.1039/B801888J
Citation: Chem. Commun., 2008,0, 3611-3621
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    Phosphate esters as “tunable” reagents in organic synthesis

    S. Protti and M. Fagnoni, Chem. Commun., 2008, 0, 3611
    DOI: 10.1039/B801888J

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