Issue 12, 2008
From the journal:

Chemical Communications

Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases†

Claudia Wanninger-Weiß,a   Francesca Di Pasquale,b   Thomas Ehrenschwender,a   Andreas Marx*b  and  Hans-Achim Wagenknecht*a  

* Corresponding authors

a University of Regensburg, Institute for Organic Chemistry, Germany
E-mail: achim.wagenknecht@chemie.uni-regensburg.de
Fax: +49 941-943-4617
Tel: +49 941-943-4802

b University of Konstanz, Department of Chemistry, Germany
E-mail: andreas.marx@uni-konstanz.de
Fax: +49 7531-88-5140
Tel: +49 7531-88-5139

Abstract

The chromophores pyrene and bordipyrromethenylbenzene directly linked to the 5-position of uridine are tolerated and recognized as thymine derivatives by DNA polymerases in primer extension experiments.

Graphical abstract: Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases

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Article information

DOI
https://doi.org/10.1039/B718002K
Article type
Communication
Submitted
20 Nov 2007
Accepted
07 Jan 2008
First published
29 Jan 2008

Chem. Commun., 2008, 1443-1445

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Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases

C. Wanninger-Weiß, F. Di Pasquale, T. Ehrenschwender, A. Marx and H. Wagenknecht, Chem. Commun., 2008, 1443 DOI: 10.1039/B718002K

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