Jump to main content
Jump to site search

Issue 6, 2008
Previous Article Next Article

Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

Author affiliations

Abstract

Chemically modified nucleotide monomers were incorporated into adjacent terminal positions of two separate oligonucleotides complementary to an RNA target; all possible combinations of the catalytic units were tested, resulting in an artificial nuclease that showed high activity and catalytic turnover.

Graphical abstract: Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Sep 2007, accepted on 26 Nov 2007 and first published on 12 Dec 2007


Article type: Communication
DOI: 10.1039/B712532A
Citation: Chem. Commun., 2008,0, 762-764
  •   Request permissions

    Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach

    M. Kalek, P. Benediktson, B. Vester and J. Wengel, Chem. Commun., 2008, 0, 762
    DOI: 10.1039/B712532A

Search articles by author

Spotlight

Advertisements