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Issue 19, 2008
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A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent

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Abstract

Several approaches towards asymmetrically derivatized peptide-decorated cyclens that yield lanthanide metal chelators, in which three of the nitrogen atoms of cyclen share a common substituent and the fourth nitrogen atom is differentially substituted, have been evaluated. The most effective route consisted of selective monoalkylation followed by peralkylation with a second different electrophile. The unique substituent also possessed a masked sulfanyl group that was suitable for subsequent chemoselective conjugation chemistry.

Graphical abstract: A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent

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Publication details

The article was received on 16 May 2008, accepted on 09 Jun 2008 and first published on 11 Jul 2008


Article type: Paper
DOI: 10.1039/B808282K
Citation: Org. Biomol. Chem., 2008,6, 3588-3596
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    A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent

    M. Suchý, A. X. Li, R. Bartha and R. H. E. Hudson, Org. Biomol. Chem., 2008, 6, 3588
    DOI: 10.1039/B808282K

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