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Issue 4, 2007
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An enantioselective Brønsted acid catalyzed enamine Mannich reaction

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Abstract

An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H8-BINOL 11a has been identified as the optimal catalyst, to afford versatile β-amino aryl ketones in good yield and enantiomeric excess.

Graphical abstract: An enantioselective Brønsted acid catalyzed enamine Mannich reaction

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Publication details

The article was received on 06 Nov 2006, accepted on 11 Dec 2006 and first published on 22 Dec 2006


Article type: Communication
DOI: 10.1039/B616143J
Citation: Org. Biomol. Chem., 2007,5, 606-609
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    An enantioselective Brønsted acid catalyzed enamine Mannich reaction

    A. L. Tillman and D. J. Dixon, Org. Biomol. Chem., 2007, 5, 606
    DOI: 10.1039/B616143J

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