Jump to main content
Jump to site search

Issue 42, 2007
Previous Article Next Article

Polymer microcapsules as mobile local pH-sensors

Author affiliations

Abstract

Polyelectrolyte microcapsules have been loaded with a pH-sensitive, high molecular weight SNARF-1-dextran conjugate. SNARF-1 exhibits a significant pH-dependent emission shift from green to red fluorescence under acidic and basic conditions, respectively. The unique spectral properties of the dye were maintained after the encapsulation. By investigating both human breast cancer cells and fibroblasts, we were able to follow the pH change of the local environment of SNARF-1-filled capsules during the transition from the alkaline cell medium to the acidic endosomal/lysosomal compartments. The incorporation of magnetite nanoparticles and an additional pH-insensitive fluorophore within the capsule shell resulted in a novel type of sensor system based on multifunctional polymer capsules.

Graphical abstract: Polymer microcapsules as mobile local pH-sensors

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Apr 2007, accepted on 22 Jun 2007 and first published on 12 Jul 2007


Article type: Paper
DOI: 10.1039/B705419J
Citation: J. Mater. Chem., 2007,17, 4471-4476
  •   Request permissions

    Polymer microcapsules as mobile local pH-sensors

    O. Kreft, A. M. Javier, G. B. Sukhorukov and W. J. Parak, J. Mater. Chem., 2007, 17, 4471
    DOI: 10.1039/B705419J

Search articles by author

Spotlight

Advertisements