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Issue 29, 2007
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α-TEPHOS: a cyclodextrin-derived tetraphosphine for multiple metal binding

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Abstract

The tetraphosphine 6A,6B,6D,6E-tetradeoxy-6A,6B,6D,6E-tetra(diphenylphosphinyl)-2A,2B,2C,2D,2E,2F,3A,3B,3C,3D,3E,3F,6C,6F-tetradeca-O-methyl-α-cyclodextrin (α-TEPHOS) has been prepared in high yield by reacting 6A,6B,6D,6E-tetra-O-methylsulfonyl-2A,2B,2C,2D, 2E,2F,3A,3B,3C,3D,3E,3F,6C,6F-tetradeca-O-methyl-α-cyclodextrin with excess PPh2Li. The product was purified in its BH3-protected form. α-TEPHOS is the first optically active tetraphosphine in which the four phosphine units are tethered to a cavity-shaped scaffold. When reacted with [AuCl(tetrahydrothiophene)], α-TEPHOS led to the corresponding tetragold complex [(α-TEPHOS)(AuCl)4] in which the four gold atoms are all located close to the primary face of the cyclodextrin. Reaction with [PdCl(o-C6H4CH2NMe2)]2 gave the C2-symmetrical complex [(α-TEPHOS){PdCl(o-C6H4CH2NMe2)}4]. Treatment of the ligand with two equiv. of [Rh(norbornadiene)(tetrahydrofuran)2]BF4 afforded selectively the bimetallic complex [(α-TEPHOS){Rh(norbornadiene)}2](BF4)2 in which each metal centre is coordinated to two phosphorus atoms belonging to adjacent glucose units.

Graphical abstract: α-TEPHOS: a cyclodextrin-derived tetraphosphine for multiple metal binding

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Publication details

The article was received on 05 Feb 2007, accepted on 03 May 2007 and first published on 24 May 2007


Article type: Paper
DOI: 10.1039/B701684K
Citation: Dalton Trans., 2007,0, 3195-3202
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    α-TEPHOS: a cyclodextrin-derived tetraphosphine for multiple metal binding

    L. Poorters, D. Armspach, D. Matt and L. Toupet, Dalton Trans., 2007, 0, 3195
    DOI: 10.1039/B701684K

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