Issue 10, 2007
From the journal:

CrystEngComm

Water mediated tube in tetrapeptide cyclo(Phe-Pro-Leu-Aha) trihydrate and crystal structure of cyclo(d-Phe-Pro-Leu-Aha) anhydrate†‡

B. M. Rajesh,a   Javed Iqbal,*a   N. Jagadeesh Babub  and  Ashwini Nangia*b  

* Corresponding authors

a Dr Reddy's Laboratories Ltd, Discovery Research, Bolarum Road, Miyapur, Hyderabad, India
E-mail: javediqbaldrf@hotmail.com
Fax: 91 40 2304 5438

b School of Chemistry, University of Hyderabad, Hyderabad, India
E-mail: ashwini_nangia@rediffmail.com
Fax: 91 40 2301 1338

Abstract

Water molecules connect 6.5 × 4.5 Å diameter rings in the X-ray crystal structure of 16-member tetrapeptide cyclo(Phe-Pro-Leu-Aha) (1) trihydrate. However, stereoisomer cyclo(D-Phe-Pro-Leu-Aha) (2) crystallized in anhydrate form. Structural differences in L- to D-amino acid exchanged cyclic peptides are analyzed.

Graphical abstract: Water mediated tube in tetrapeptide cyclo(Phe-Pro-Leu-Aha) trihydrate and crystal structure of cyclo(d-Phe-Pro-Leu-Aha) anhydrate

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Article information

DOI
https://doi.org/10.1039/B709700J
Article type
Communication
Submitted
26 Jun 2007
Accepted
20 Jul 2007
First published
06 Aug 2007

CrystEngComm, 2007,9, 860-864

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Water mediated tube in tetrapeptide cyclo(Phe-Pro-Leu-Aha) trihydrate and crystal structure of cyclo(D-Phe-Pro-Leu-Aha) anhydrate

B. M. Rajesh, J. Iqbal, N. J. Babu and A. Nangia, CrystEngComm, 2007, 9, 860 DOI: 10.1039/B709700J

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