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Issue 43, 2007
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Regioselectivity and enantioselectivity in nickel-catalysed reductive coupling reactions of alkynes

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Abstract

Nickel-catalysed reductive coupling reactions of alkynes have emerged as powerful synthetic tools for the selective preparation of functionalized alkenes. One of the greatest challenges associated with these transformations is control of regioselectivity. Recent work from our laboratory has provided an improved understanding of several of the factors governing regioselectivity in these reactions, and related studies have revealed that the reaction mechanism can differ substantially depending on the ligand employed. A discussion of stereoselective transformations and novel applications of nickel catalysis in coupling reactions of alkynes is also included.

Graphical abstract: Regioselectivity and enantioselectivity in nickel-catalysed reductive coupling reactions of alkynes

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Publication details

The article was received on 22 May 2007, accepted on 18 Jun 2007, published on 03 Jul 2007 and first published online on 03 Jul 2007


Article type: Feature Article
DOI: 10.1039/B707737H
Citation: Chem. Commun., 2007, 4441-4449
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    Regioselectivity and enantioselectivity in nickel-catalysed reductive coupling reactions of alkynes

    R. M. Moslin, K. Miller-Moslin and T. F. Jamison, Chem. Commun., 2007, 4441
    DOI: 10.1039/B707737H

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