Issue 27, 2007

A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

Abstract

We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.

Graphical abstract: A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2007
Accepted
21 May 2007
First published
12 Jun 2007

Chem. Commun., 2007, 2808-2810

A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

S. J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. M. Napier, M. J. Sergeant, A. J. Thompson and P. C. Taylor, Chem. Commun., 2007, 2808 DOI: 10.1039/B704271J

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