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Issue 20, 2007
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Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

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Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Graphical abstract: Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

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Publication details

The article was received on 02 Jan 2007, accepted on 17 Jan 2007 and first published on 22 Feb 2007


Article type: Communication
DOI: 10.1039/B618923G
Citation: Chem. Commun., 2007,0, 2075-2077
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    Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids

    F. Kopp, S. Wunderlich and P. Knochel, Chem. Commun., 2007, 0, 2075
    DOI: 10.1039/B618923G

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