Issue 6, 2007
From the journal:

Chemical Communications

Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio†

Wei-Jun Tang,a   Shou-Fei Zhu,b   Li-Jin Xu,*a   Qi-Lin Zhou,b   Qing-Hua Fan,*c   Hai-Feng Zhou,c   Kimhung Lama  and  Albert S. C. Chan*a  

* Corresponding authors

a Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong, P. R. China
E-mail: bcachan@polyu.edu.hk
Fax: (+852)-2364-9932

b State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, China

c Institute of Chemistry, The Chinese Academy of Sciences, Beijing, P. R. China
E-mail: fanqh@iccas.ac.cn
Fax: (+86)-10-62554472

Abstract

The chiral diphosphinite ligand derived from (R)-1,1′-spirobiindane-7,7′-diol has been found to be highly effective in the Ir-catalyzed asymmetric hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).

Graphical abstract: Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio

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Article information

DOI
https://doi.org/10.1039/B614446B
Article type
Communication
Submitted
05 Oct 2006
Accepted
23 Oct 2006
First published
07 Nov 2006

Chem. Commun., 2007, 613-615

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Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio

W. Tang, S. Zhu, L. Xu, Q. Zhou, Q. Fan, H. Zhou, K. Lam and A. S. C. Chan, Chem. Commun., 2007, 613 DOI: 10.1039/B614446B

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