Issue 5, 2007
From the journal:

Chemical Communications

Exploring a new, connective Pummerer reaction: formation of oxindoles by the reaction of thiols with glyoxamides†

Marc Miller,a   William Tsang,a   Andrew Merrittb  and  David J. Procter*a  

* Corresponding authors

a School of Chemistry, University of Manchester, Oxford Rd., Manchester, UK
E-mail: david.j.procter@manchester.ac.uk

b GlaxoSmithKline, Gunnelswood Rd., Stevenage, UK

Abstract

The reaction of a range of thiols with mono- and bis-glyoxamides derived from secondary anilines, triggers a new, connective Pummerer cyclisation process and leads to the formation of oxindoles.

Graphical abstract: Exploring a new, connective Pummerer reaction: formation of oxindoles by the reaction of thiols with glyoxamides

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Article information

DOI
https://doi.org/10.1039/B613591A
Article type
Communication
Submitted
19 Sep 2006
Accepted
16 Oct 2006
First published
31 Oct 2006

Chem. Commun., 2007, 498-500

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Exploring a new, connective Pummerer reaction: formation of oxindoles by the reaction of thiols with glyoxamides

M. Miller, W. Tsang, A. Merritt and D. J. Procter, Chem. Commun., 2007, 498 DOI: 10.1039/B613591A

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