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Issue 4, 2007
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Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

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Abstract

We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.

Graphical abstract: Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

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Publication details

The article was received on 29 Aug 2006, accepted on 20 Oct 2006 and first published on 01 Nov 2006


Article type: Communication
DOI: 10.1039/B612353H
Citation: Chem. Commun., 2007,0, 419-421
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    Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

    A. M. Chen, M. E. Ellison, A. Peresypkin, R. M. Wenslow, N. Variankaval, C. G. Savarin, T. K. Natishan, D. J. Mathre, P. G. Dormer, D. H. Euler, R. G. Ball, Z. Ye, Y. Wang and I. Santos, Chem. Commun., 2007, 0, 419
    DOI: 10.1039/B612353H

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