Issue 17, 2006

Synthesis of the C1–C16 fragment of ionomycin using a neutral (η3-allyl)iron complex

Abstract

Key steps in the synthesis of the C1–C16 polyketide fragment of ionomycin were the nucleophilic addition of an organocuprate to a neutral (η3-allyl)iron complex and the construction of a β-diketone moiety by the Rh-catalysed rearrangement of an α-diazo-β-hydroxyketone.

Graphical abstract: Synthesis of the C1–C16 fragment of ionomycin using a neutral (η3-allyl)iron complex

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2006
Accepted
07 Jul 2006
First published
31 Jul 2006

Org. Biomol. Chem., 2006,4, 3325-3336

Synthesis of the C1–C16 fragment of ionomycin using a neutral (η3-allyl)iron complex

J. P. Cooksey, P. J. Kocienski, Y. Li, S. Schunk and T. N. Snaddon, Org. Biomol. Chem., 2006, 4, 3325 DOI: 10.1039/B606262H

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