Issue 8, 2006
From the journal:

Organic & Biomolecular Chemistry

Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives

Kristian Rahbek Knudsen,a   Antonia F. Stepan,a   Patrick Michela  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 (0) 1223 336442

Abstract

Diastereoselective aldol coupling reactions with butane-2,3-diacetal (BDA) protected glyceraldehyde derivatives are reported. Good selectivities of up to 20 : 1 for the homologated aldol products have been achieved in preparatively useful yields.

Graphical abstract: Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives

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Article information

DOI
https://doi.org/10.1039/B601888B
Article type
Communication
Submitted
07 Feb 2006
Accepted
21 Feb 2006
First published
13 Mar 2006

Org. Biomol. Chem., 2006,4, 1471-1473

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Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives

K. R. Knudsen, A. F. Stepan, P. Michel and S. V. Ley, Org. Biomol. Chem., 2006, 4, 1471 DOI: 10.1039/B601888B

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