Issue 29, 2006

Enantioselective synthesis of β-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine

Abstract

β-Amino esters are readily formed from the rhodium(II) prolinate-catalyzed intermolecular C–H insertion between methyl aryldiazoacetates and a bis-silyl protected methylamine.

Graphical abstract: Enantioselective synthesis of β-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine

Supplementary files

Article information

Article type
Communication
Submitted
06 Apr 2006
Accepted
21 May 2006
First published
14 Jun 2006

Chem. Commun., 2006, 3110-3112

Enantioselective synthesis of β-amino esters and its application to the synthesis of the enantiomers of the antidepressant Venlafaxine

H. M. L. Davies and A. Ni, Chem. Commun., 2006, 3110 DOI: 10.1039/B605047F

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