Issue 7, 2005
From the journal:

Organic & Biomolecular Chemistry

On the origin of the DNA sequence selectivity of the azinomycins

Rachel C. LePla,a   Cyrille A. S. Landreau,a   Michael Shipman*a  and  George D. D. Jonesb  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: m.shipman@warwick.ac.uk
Fax: +44 24765 24429
Tel: +44 24765 23186

b Department of Cancer Studies & Molecular Medicine, University of Leicester, University Road, Leicester, UK
E-mail: gdj2@leicester.ac.uk
Fax: +44 11622 31840
Tel: +44 11622 31841

Abstract

Simplified synthetic azinomycins preferentially induce in vitro DNA interstrand cross-links at the same 5′-d(GCC)-3′ site as the natural products revealing that non-covalent interactions are relatively unimportant in defining sequence specificity.

Graphical abstract: On the origin of the DNA sequence selectivity of the azinomycins

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Article information

DOI
https://doi.org/10.1039/B502188J
Article type
Communication
Submitted
11 Feb 2005
Accepted
21 Feb 2005
First published
01 Mar 2005

Org. Biomol. Chem., 2005,3, 1174-1175

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On the origin of the DNA sequence selectivity of the azinomycins

R. C. LePla, C. A. S. Landreau, M. Shipman and G. D. D. Jones, Org. Biomol. Chem., 2005, 3, 1174 DOI: 10.1039/B502188J

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