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Issue 2, 2005
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Total synthesis of the Fusarium toxin equisetin

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Abstract

A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels–Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted γ,δ-unsaturated β-ketothioester.

Graphical abstract: Total synthesis of the Fusarium toxin equisetin

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Publication details

The article was received on 23 Jul 2004, accepted on 03 Nov 2004 and first published on 07 Dec 2004


Article type: Paper
DOI: 10.1039/B411350K
Citation: Org. Biomol. Chem., 2005,3, 274-280
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    Total synthesis of the Fusarium toxin equisetin

    L. T. Burke, D. J. Dixon, S. V. Ley and F. Rodríguez, Org. Biomol. Chem., 2005, 3, 274
    DOI: 10.1039/B411350K

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